Synthesis And Anagesic activities of Quinazolin-4(3H)-One, 2-Methyl-4(3H)-Quinazolinone and 2–Phenyl-4(3H)-quinazolin-4(3H)–one
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چکیده
منابع مشابه
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones.
A series of novel 2-methyl-3-substituted quinazolin-4-(3H)-ones have been synthesized by treating (2-methyl-4-oxo-3H-quinazolin-3-yl)dithiocarbamic acid methyl ester with different amines, the starting material dithiocarbamate was synthesized from anthranilic acid. The compounds synthesized were investigated for analgesic, anti-inflammatory and antibacterial activities. All the test compounds e...
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In the title mol-ecule, C(16)H(15)FN(4)O, the dihedral angle between the fluoro-substituted benzene ring and the pyrimidinone ring is 52.34 (7)°, while the dihedral angle between the fused benzene ring and the pyrimidinone ring is 3.30 (6)°. An intra-molecular N-H⋯N hydrogen bond may, in part, influence the conformation of the mol-ecule. In the crystal structure, inter-molecular N-H⋯N hydrogen ...
متن کامل6′-Methyl-1′,2′,3′,4′-tetrahydrospirocyclohexane-2′-quinazolin-4′-one
The title compound, C(14)H(18)N(2)O, was synthesized by the reaction of cyclo-hexa-none and 2-amino-5-methyl-benzonitrile. In the mol-ecule, the cyclo-hexane ring displays a chair conformation, whereas the 1,3-diaza-cyclo-hexane moiety of the bicyclic system has a sofa conformation with the spiro C atom displaced by 0.603 (2) Å from the rest of the atoms of the 1,3-diaza-cyclo-hexane ring [plan...
متن کاملSynthesis of Some New 2-substituted Quinazolin-4- One Derivatives and Their Biological Activties
A series of mannich bases (3a-3j) were synthesized by the reaction of 4-[2-methyl-4-oxo-4H-quinazolin-3-yl] benzoic acid (2) with formaldehyde and appropriate amines by conventional technique. The procedure afforded various quinazolinone derivatives with 75% yield. Structures were characterized by means of spectral data. All the synthesized compounds were subjected to biological evaluation for ...
متن کامل8-Benzyloxy-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one
In the title methaqua-lone analogue, C(23)H(20)N(2)O(2), the planes of the terminal aromatic rings [dihedral angle between them = 64.52 (7)°] approximately face the fused-ring methyl group and both are twisted with respect to the pyrimidine plane (r.m.s. deviation = 0.028 Å), forming dihedral angles of 86.9 (3) (with the 2-tolyl ring) and 65.57 (7)°. The 2-tolyl residue is disordered over two a...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2020
ISSN: 2250-1177
DOI: 10.22270/jddt.v10i4-s.4209